The US Food and Drug Administration said Thursday that drugmaker Endo Pharmaceuticals must remove its powerful opioid Opana ER from the market. The agency says this the first time it has asked that an opioid pain medication be pulled due to “the public health consequences of abuse.”
“We are facing an opioid epidemic — a public health crisis — and we must take all necessary steps to reduce the scope of opioid misuse and abuse,” FDA Commissioner Dr. Scott Gottlieb said. “We will continue to take regulatory steps when we see situations where an opioid product’s risks outweigh its benefits, not only for its intended patient population but also in regard to its potential for misuse and abuse.”
If Opana ER sounds familiar, it’s because it was the drug of choice for many addicts at the center of an HIV outbreak in Indiana in 2015.
The drug is about twice as powerful as OxyContin, another often abused opioid. Opana ER, oxymorphone hydrochloride, is used to manage pain severe enough to require daily, around-the-clock, long-term opioid treatment for which alternatives aren’t strong enough, according to the manufacturer’s website. The FDA approved it for this use in 2006.
“My comment is ‘wow,’ ” said Dr. Andrew Kolodny, co-director of opioid policy research at the Heller School for Social Policy and Management at Brandeis University. “This is pretty exciting. This is big news.”
Though it is a “good sign” for the fight against opioid abuse, he said, “Opana is not the only one that needs to come off the market.”
Endo had tried to make it harder for addicts to use Opana ER by making it with a coating that made it hard to crush. The medication is intended to release over time, but addicts had been crushing it to get a massive high all at once.
When the drugmaker changed the formula in 2012, some addicts began injecting it instead. In the Indiana case, the shared needles helped spread the HIV infection to over 142 people.
The FDA said it made its latest decision based on a review of all post-market data, which suggested that when the company reformulated the medication, people were injecting it more than they were snorting it. This method of delivery also caused a serious outbreak of hepatitis C and a serious blood disorder, according to the agency.
Thursday’s announcement followed a March vote from an independent group of experts, brought together by the FDA, who voted 18-8 that the benefits of reformulation no longer outweighed the risks.
Endo has had other issues with the FDA and the drug. When the company submitted its reformulated version to the FDA in 2012, the agency decided the data weren’t strong enough to show that it could “meaningfully reduce abuse,” and the agency denied a request to include a label that would describe its reformulation as having abuse-deterrent properties.
The United States in in the midst of an opioid overdose epidemic, according to the US Centers for Disease Control and Prevention. Opioid overdose killed more than 33,000 people in 2015, more than any year on record. Nearly half of all overdose deaths involve some kind of prescription drug.
Endo has not returned a request for comment. The FDA said Thursday that if the company does not pull Opana ER off the market, the agency will take steps to formally require its removal.
